Preheat your air fryer to 400°F (200°C).

Spray the mahi mahi fillets lightly with avocado oil.

Season both sides of the fillets with garlic powder, onion powder, salt, and pepper.

Place the seasoned mahi mahi fillets in the air fryer basket in a single layer.

Cook at 400°F (200°C) for about 8 minutes, flipping halfway through cooking, until the fish is golden brown and reaches an internal temperature of 145°F (63°C).